
Dogs have the largest variation in body size of any land animal, so researchers led by Elaine A. Ostrander of the National Human Genome Research Institute decided to look into the reasons why.
K. Gordon Lark of the University of Utah, a co-author of the report, pointed out that dogs have 200 to 300 diseases in common with people, including high blood pressure, autoimmune diseases and cancer.
Known as a regulatory sequence, the difference is on dog chromosome 15 next to a previously known gene named IGF1, for insulin-like growth factor 1. The hormone controlled by the IGF1 gene helps mammals — including people — grow from birth to adolescence.
In small dog breeds a mutation in the sequence next to the gene kept them from growing larger, the researchers said.
No comments :
Post a Comment